Meeting/Event Information

    Dr. Andrew Lee (NU) "Rational Cancer Vaccine Design Based on Spherical Nucleic Acids"

    January 25, 2019
    5:30 PM to 9:00 PM
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    Roosevelt University - Schaumburg
    1400 N Roosevelt Rd
    Schaumburg,, IL 60173
    https://www.roosevelt.edu/why-roosevelt/schaumburg
     Directions

    Joint meeting with AIChE

    Dr. Andrew Lee

    - Northwestern University -
    Dept. of Chemical and Biological Engineering

    "Rational Cancer Vaccine Design Based on Spherical Nucleic Acids"

    ABSTRACT

    Nanomedicine stands to make major contributions to immunotherapy. Nanostructures that can be designed to present and deliver immunestimulatory molecules to cells of the immune system provide a way to boost, modulate and tune immune responses to disease. Spherical nucleic acids (SNAs) are a specific and promising class of nanostructure that are we are developing as immunotherapeutic vaccines for cancer. In spite of what is known about the molecular pathways for immune system stimulation and antigens specific for many types of cancer, cancer vaccines have historically not shown outstanding success clinically. What remains poorly understood is how best to deliver and present antigen and adjuvant molecules to the immune system. SNAs have the characteristic feature of a nanoparticle core presenting chemically functionalized TLR agonist oligonucleotides at high surface density. SNAs are structurally well-defined and modular in nature; through synthetic chemistry, we have controlled several structural features of SNAs independently (e.g., core composition and size, position of antigen). This approach has enabled our rational design of vaccines based on SNA structures and has identified several structural features critical for stimulating anti-cancer immune responses. We have found that variations in the structures of SNAs, those that are compositionally equivalent but structurally distinct, lead to major differences in the quality of induced antigen-specific immune responses. Our development of SNAs as potential cancer vaccines has not only led to the identification of structures that generate anti-tumor responses and survival benefits in vivo, but has also allowed us to establish the structural and mechanistic basis for function and to drive further improvements in vaccine design.

    PROGRAM

    • 5:30 - 6:30  Registration and Poster Session
    • 6:00 - 6:20  Pre-dinner presentation: Joel Schoenberg (Chicago ACS YCC Chair)
    • 6:30 - 7:30  Dinner 
    • 7:30 - 7:45  Introductory remarks
    • 7:45 - 8:30  Main Lecture

    LOCATIONS:

    MAIN SITE (With live speaker): Roosevelt University - Schaumburg
    REMOTE LOCATION #1: Purdue University Northwest (Hammond, IN)

    TEACHERS! All K-12 educators can receive continuing education credits for attending our meetings. Get your CE form at the registration desk.


    POSTER SESSION

    Undergraduates can present posters describing their research, and the best one will win a prize! Register your poster here:

     ** http://chicagoacs.org/form.php?form_id=47 **

    ! Did you present a poster at a recent conference? Bring it out and present it again!

     

     


    PRE-DINNER EVENT:

    Joel Shoenburg, YCC Chair
    "Lead, the versatile metal that fixed engine knock"

    This short presentation dives into a portion of the book, "Prometheans in the Lab." Most people today know that lead poses some health risk. But the book transports us to a time where lead was everywhere, even in our toothpaste containers. I would like to talk about the driving factors in science when health was no issue. What did leaded fuel succeed at doing? What did it fail at?

    DINNER

    MAIN SITE
    Roosevelt University - Schaumburg
    BUFFET
    • Entrees: Rosemary chicken, Vegetable lasagna in tomato cream sauce
    • Garden salad, tricolor roasted potatoes, roasted vegetable medley, dinner roll
    • Dessert, beverage
    REMOTE SITE #1
    Purdue U. Northwest
    No dinner provided, but you are welcome to bring your own

    RESERVATIONS:

    Dinner Registration Deadline: 12:00 Noon on Tuesday, January 22
    Lecture-only Registration Deadline: 12:00 noon Thursday, January 24

    QUESTIONS OR NON-WEB RESERVATIONS?  Please contact the Section Office via phone (847-391-9091) or email (info@chicagoacs.org).


    BIOGRAPHY

    Andrew Lee is a Research Assistant Professor at Northwestern University, in the Department of Chemical and Biological Engineering. Following his PhD training in chemistry at Harvard University post-doctoral training at Northwestern University, he began an appointment as an independent investigator at Northwestern University. Andrew Lee’s activity in nanomedicine research involves the development of spherical nucleic acid (SNA) nanostructures as therapeutic agents for the treatment of cancer (immunotherapeutic or gene regulatory mechanisms of action), in research programs led by Professor Chad Mirkin at Northwestern University. This research is examining the chemical composition and structure of SNAs (the core, oligonucleotide, and antigen and peptide-conjugation chemistries) as the drivers of the ability of SNAs to function as agents that enter targeted cells and enhance the activity of therapeutic oligonucleotides (as immunostimulatory compounds). These research efforts are supported by the National Cancer Institute and Prostate Cancer Foundation. Related research projects, aimed at innovating vaccine immunotherapy for prostate cancer, are focused on discovering neoantigens through the identification of post-translationally modified proteins and analysis of the immunogenicity of these proteins.

    MAIN LOCATION - DIRECTIONS and PARKING:

    LIVE LECTURE:

    Roosevelt University - Schaumburg
    1400 Roosevelt Rd., Room TBD
    Schaumburg, IL 60173

    Map & Directions: http://chicagoacs.org/images/downloads/Maps_of_venues/venuemap_rooseveltschaumburg_2017.pdf

    PARKING: Free in adjacent lot


    STREAMING LOCATIONS - DIRECTIONS and PARKING:

    STREAMING LOCATION #1:

    Purdue University Northwest
    Gyte Building, Room 240
    2200 169th St.
    Hammond, IN  46323

    Map: http://chicagoacs.org/images/downloads/Maps_of_venues/purduenw_map.pdf

    PARKING: free 

     

    Tickets

    $15.00 MAIN SITE DINNER - Member ticket

    $15.00 MAIN SITE DINNER - AIChE member ticket

    $17.00 MAIN SITE DINNER - Nonmember ticket

    $0.00 MAIN SITE - Lecture only registration

    $0.00 REMOTE SITE #1 - Lecture only registration

    $0.00 Individual Donation (flexible amount)

    $0.00 Company Sponsorship (flexible amount)

    $0.00 Donation to Project SEED (flexible amount)

    Documents

    Printable meeting flyer